HPE P40481-B21 800GB SAS 24Gb/s Write Intensive 2.5-Inch Solid State Drive with Basic Carrier for ProLiant DL380 Gen10. In Stock Brand: HPE Part Number: P40481-B21 Category: SSD Key Specs: 800GB Availability: In Stock Shipping: Fast US-based shipping Order the HPE P40481-B21 today from ProDisk Network — your trusted source for enterprise IT hardware. All products are quality-tested and backed by our support team.
The P40481-B21 is a HPE ssds component with capacity 800 GB, form factor 2.5-inch, interface SAS. Pricing on the P40481-B21 is quote-based — email sales@prodisknetwork.com or use our live chat for a quote within one business day.
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Reviewed by:Pro Disk Network Engineering Team — . Specifications, compatibility, and pricing for the P40481-B21 are shown on this page.
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Quick Answer: Will the P40481-B21 work with my RAID controller?
The P40481-B21 operates with any standard SAS/SATA/NVMe-compatible RAID controller (Dell PERC, HPE Smart Array, LSI/Broadcom MegaRAID, Adaptec, IBM ServeRAID, Lenovo ThinkSystem RAID). Mixing this drive in the same RAID volume with drives of different speed/capacity is supported but never recommended.
How fast does the P40481-B21 ship?
P40481-B21 orders placed before 3 pm ET ship the same business day from US warehouses. Delivery is next business day to most metro ZIPs via FedEx/UPS overnight; ground delivery covers remaining US in 1-4 business days.
The P40481-B21 is deployed by US enterprises, MSPs, government, and education customers across multiple infrastructure scenarios. Below are the most common deployment patterns Pro Disk Network sees in real-world orders.
VMware Datastore — ESXi 7/8 datastores hosting 30–80 VMs per drive. RAID 10 for write-intensive, RAID 5 for read-leaning VM mixes.
Citrix / Horizon VDI — Linked-clone master images and write-cache disks. Lower DWPD acceptable since VDI write patterns are bursty.
NoSQL & Real-Time Analytics — MongoDB, Cassandra, ClickHouse, Druid hot-tier nodes. NVMe variant strongly preferred over SAS/SATA for query latency.
Hypervisor Boot — ESXi, Hyper-V, Proxmox boot drives. Read-intensive (1 DWPD) is sufficient. Mirror two drives for redundancy.
What is the P40481-B21?
The P40481-B21 is a HPE enterprise solid-state drive with capacity 800 GB and form factor 2.5-inch, manufactured by HPE. Pro Disk Network ships this part new and certified-refurbished from our US warehouse with same-day dispatch on orders placed before 3 PM ET, backed by a 30-day return guarantee.
Pros & Cons of P40481-B21
Pros
Same-day US shipping from our US warehouse
Cons
Not recommended for OLTP databases above 50 TPS
Mechanical drive — expect 5–10W idle power per unit
3.5" form factor only — confirm caddy fit before ordering
Frequently Asked Questions about P40481-B21
Is the P40481-B21 a genuine HPE part?
Yes. Pro Disk Network sources every P40481-B21 as factory-original HPE inventory. New units arrive sealed in OEM packaging; refurbished units are pulled from decommissioned HPE servers, surface-tested, and re-warranted by Pro Disk Network for 90 days.
Will the P40481-B21 work with my RAID controller?
The P40481-B21 operates with any standard SAS/SATA/NVMe-compatible RAID controller (Dell PERC, HPE Smart Array, LSI/Broadcom MegaRAID, Adaptec, IBM ServeRAID, Lenovo ThinkSystem RAID). Mixing this drive in the same RAID volume with drives of different speed/capacity is supported but never recommended.
How fast does the P40481-B21 ship?
P40481-B21 orders placed before 3 pm ET ship the same business day from US warehouses. Delivery is next business day to most metro ZIPs via FedEx/UPS overnight; ground delivery covers remaining US in 1-4 business days.
What is the warranty on the P40481-B21?
New P40481-B21 units carry the full HPE manufacturer warranty (typically 1 to 5 years depending on product line). Refurbished and bulk-OEM units include a Pro Disk Network advance-replacement warranty (90 days refurbished). DOA replacement is free within 30 days of receipt.
Do you offer bulk pricing for the P40481-B21?
Email sales@prodisknetwork.com with the quantity and target ship date for a quote within one business day.
How to Pick the Right Drive Capacity for Your Use Case
For VMware vSAN deployments, the P40481-B21 is best deployed in the capacity tier with NVMe cache drives in front. Size the cache layer at 10% of usable capacity for write-intensive workloads and 5% for read-leaning workloads. For Veeam backup repositories, plan around 1.5× the size of your protected estate to allow for incremental forever chains plus synthetic fulls. Splunk warm tier sizing should follow the daily ingest rate × retention days × 1.6 compression overhead.
Drive Health Monitoring: SMART, Workload Rating, and Predictive Failure
For VMware ESXi 8 hosts, enable vSphere's predictive-failure analysis on the P40481-B21 via the host's storage device list. The host queries SMART on a regular cadence and surfaces yellow/red warnings in vCenter before the drive fails outright. On Linux, use smartctl piped to your monitoring system; on Windows Server, Storage Spaces exposes health state directly in Server Manager.