HPE ProLiant Gen11 Memory: DDR5 Part Numbers for DL360 & DL380
HPE ProLiant DL360 and DL380 Gen11 take DDR5 ECC RDIMMs only: DDR5-4800 kits with 4th Gen Xeon (P43328-B21 32GB, P43331-B21 64GB) and DDR5-5600 kits with 5th Gen Xeon (P64706-B21 32GB, P64707-B21 64GB). HPE supports only 1, 2, 4, 6, 8, 12 or 16 DIMMs per processor. Part numbers, speeds and population rules from HPE documents.
TL;DR — Direct Answer
HPE ProLiant Gen11 servers (DL360 Gen11, DL380 Gen11, and siblings) use DDR5 ECC RDIMM memory (up to 4800 MT/s with 4th Gen Xeon, up to 5600 MT/s with 5th Gen Xeon) — and only that. You cannot use DDR4, and you cannot use desktop/UDIMM modules: DDR5 has a different physical key, so older DIMMs will not seat.
The common HPE Smart Memory Gen11 part numbers:
| Capacity | With 4th Gen Xeon (DDR5-4800) | With 5th Gen Xeon (DDR5-5600) |
|---|---|---|
| 16 GB 1Rx8 | P43322-B21 | P64705-B21 |
| 32 GB 2Rx8 | P43328-B21 | P64706-B21 |
| 64 GB 2Rx4 | P43331-B21 | P64707-B21 |
| 96 GB 2Rx4 | P66675-B21 | P64708-B21 |
| 128 GB 4Rx4 3DS | P43334-B21 | P64709-B21 |
| 256 GB 8Rx4 3DS | P43337-B21 | P64710-B21 |
The kit must match the processor: HPE supports DDR5-4800 kits only with 4th Gen Xeon, and 5th Gen processors support only PC5-5600B/5200B memory. HPE also lists a 32 GB 1Rx4 (P43325-B21), 128 GB 2Rx4 (P69974-B21 / P69976-B21) and 256 GB 4Rx4 3DS (P90550-B21 / P90554-B21). Sources: HPE's Gen11 memory population white papers (a50007437ENW, a50010242ENW) and the DL360/DL380 Gen11 QuickSpecs. Below are the rules that keep a configuration supported and at full speed.
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Why Gen11 is DDR5-only
Gen11 moved to 4th/5th-Gen Intel Xeon Scalable (and AMD EPYC on some models), which dropped DDR4 support entirely. DDR5 brings higher bandwidth, on-die ECC, and per-module power management — but it is not backward compatible. The notch position on a DDR5 DIMM is different from DDR4, so a DDR4 stick physically will not fit a Gen11 slot. If you are coming from a Gen10/Gen10 Plus, your old memory does not carry over.
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Population rules (from HPE's Gen11 white papers)
- Only seven DIMM counts per processor are supported: 1, 2, 4, 6, 8, 12 or 16. HPE: "Configurations not listed are not supported and if populated, the server may not boot." With two processors, install the same count on each.
- 8 per processor is the full-bandwidth layout: one DIMM on each of the 8 channels, in slots 1, 3, 5, 7, 10, 12, 14 and 16. 16 per processor fills every slot at a lower speed; 12 per processor gives two interleave regions, and HPE rates the slower one at 50% of peak.
- Speed with one or two DIMMs per channel (HPE server memory speed, MT/s): 4th Gen Platinum and Gold 64xx 4800 / 4400; Gold 54xx 4400 / 4400; Silver 44xx and Bronze 34xx 4000 / 4000. 5th Gen Platinum 85xx 5600 / 4400; Gold 65xx 5200 / 4400; Gold 55xx 4800 / 4400; Silver and Bronze 4400 / 4400. Some processors are slower than their family (for example Gold 6430: 4400).
- 96 GB DIMMs: with 4th Gen only at 8 or 16 per processor; with 5th Gen not at 2 or 4 per processor and not on EE LCC processors; never mixed with another capacity.
- DL380 Gen11 with the 24SFF drive cage takes at most 16 DIMMs in total (HPE QuickSpecs).
- Use HPE Smart Memory: HPE's speed tables and rules are written for it.
Check a plan against these rules, slot by slot, with the HPE server memory configurator.
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New vs tested/refurbished memory
DDR5 server memory is expensive. Memory has no moving parts and effectively no wear, which makes pulled DDR5 RDIMMs one of the lowest-risk ways to cut a Gen11 build cost, with the same HPE part number and a warranty. For a 12- or 24-DIMM DL380 Gen11, that adds up fast.
See our Server RAM Buying Guide: DDR4 vs DDR5 ECC for the deeper RDIMM/LRDIMM and speed-tier discussion.
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Frequently Asked Questions
Does HPE ProLiant Gen11 use DDR4 or DDR5?
DDR5 only — specifically DDR5 ECC RDIMM (4800 MT/s with 4th Gen Xeon, up to 5600 MT/s with 5th Gen Xeon). DDR4 will not physically fit (DDR5 is keyed differently), so Gen10/Gen10 Plus memory does not carry over to Gen11.
What memory does a DL380 Gen11 take?
DDR5 ECC RDIMM (3DS RDIMM for 128 GB and 256 GB), up to 32 DIMMs and 8 TB. With 4th Gen Xeon use the DDR5-4800 kits, such as P43328-B21 (32GB), P43331-B21 (64GB) and P43334-B21 (128GB); with 5th Gen Xeon the DDR5-5600 kits, such as P64706-B21, P64707-B21 and P64709-B21.
Can I mix different HPE memory part numbers in a Gen11?
Only a few pairs. HPE allows 16 GB 1Rx8 with 32 GB 2Rx8, 32 GB 1Rx4 with 64 GB 2Rx4 (4th Gen kits only), and 128 GB 4R 3DS with 256 GB 8R 3DS, and only with all 16 slots per processor filled, the higher-rank DIMM in the white slots. Every other mix, including any with 96 GB DIMMs or x4 with x8 DIMMs, is not supported.
Is refurbished/tested DDR5 server memory reliable?
Yes — memory has no mechanical wear, and refurbished modules carry the same HPE PN as new. It's a common way to save on a Gen11 build.
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Where to buy
Pro Disk Network quotes Gen11 DDR5 kits on request: tell us the server, processors and target capacity, or send a plan from the memory configurator, and we'll confirm part numbers, availability and price. Browse HPE server memory and DDR5 server memory, or contact us.
Related: HP ProLiant DL380 Gen11 vs Gen10 Plus vs Gen10 · Cisco & HPE End-of-Life Guide