Replacement for P06251-B21: Drop-In Alternatives We Stock
Looking for a replacement for the P06251-B21 (HPE P06251-B21 InfiniBand HDR100/Ethernet 2-Ports 100GbE QSFP56 PCI Express 3.0 x16 Network Adapter for ProLiant Gen10 Server)? Pro Disk Network ships HP drop-in replacements and equivalent modern parts from US inventory. Every alternate below is in-stock today with same-day shipping for orders placed before 2pm ET. If your unit is still under warranty, contact our engineering team — we offer cross-shipping for B2B customers on Net 30 terms.
About the P06251-B21
| SKU | P06251-B21 |
|---|---|
| Product | HPE P06251-B21 InfiniBand HDR100/Ethernet 2-Ports 100GbE QSFP56 PCI Express 3.0 x16 Network Adapter for ProLiant Gen10 Server |
| Current price | $726.32 |
| Stock status | In Stock |
| Detail page | View P06251-B21 › |
Drop-in replacements for P06251-B21
Each part below is currently in our US warehouse, ships same-day for orders before 2pm ET, and includes our 90-day warranty. SKUs link to the full product page with photos, datasheets and B2B quote form.
HPE P08355-001 InfiniBand HDR100/Ethernet 2-Ports 100GbEPCI-Express 3.0 x16 Low-Profile Gigabit Ethernet Network Adapter
SKU: P08355-001
Price: $549.47
HPE 877691-B21 InfiniBand EDR/Ethernet 841QSFP28 2-Ports 100GbE PCI Express 3.0 x16 Network Adapter for ProLiant Server
SKU: 877691-B21
Price: $305.26
HPE 872726-H21 Infiniband Edr/Ethernet 2-Ports 100GbE QSFP28 PCI-Express 3.0 x16 Network Adapter for ProLiant DL580 Gen10
SKU: 872726-H21
Price: $305.26
HPE P23842-001 InfiniBand EDR/Ethernet 841QSFP28 2-Ports 100GbE PCI Express 3.0 x16 Network Adapter for ProLiant Server
SKU: P23842-001
Price: $378.95
HPE P24752-001 Infiniband HDR100/Ethernet 2-Ports 100GBase-X QSFP56 PCI-Express 4.0 x16 Low-Profile Network Adapter
SKU: P24752-001
Price: $608.42
HPE P24249-001 Infiniband HDR100/Ethernet 2-Ports 100GBase-X QSFP56 PCI-Express 4.0 x16 Low-Profile Network Adapter
SKU: P24249-001
Price: $608.42
HPE 778509-B21 InfiniBand FDR 2 x Ports QSFP+ 56Gb/s PCI Express 3.0 x8 Network Adapter
SKU: 778509-B21
Price: $421.05
HPE P24252-001 InfiniBand HDR100 2-Ports 100Gb/s 100GBase-X QSFP28 PCI Express 4.0 x16 Network Adapter for ProLiant Dl Rack Mount Gen10
SKU: P24252-001
Price: $608.42
HPE P24255-B21 InfiniBand HDR100 2-Ports 100Gb/s 100GBase-X QSFP28 PCI Express 4.0 x16 Network Adapter for ProLiant Dl Rack Mount Gen10
SKU: P24255-B21
Price: $608.42
HPE R7R45A InfiniBand HDR/100 2-Ports 100Gb/s QSFP28 PCI Express 4.0 x16 Network Adapter
SKU: R7R45A
Price: $629.47
HPE P23665-B21 InfiniBand HDR100/Ethernet 1-Port 100GbE QSFP56 PCI Express 4.0 x16 Network Adapter
SKU: P23665-B21
Price: $534.74
HPE P23664-H21 1x Port 200GbE QSFP56 HDR/Ethernet PCI Express 4.0 x16 InfiniBand Network Adapter
SKU: P23664-H21
Price: $1,570.53
How we pick replacements
Every recommendation above was selected using these criteria:
- Drop-in compatibility — same form factor (2.5"/3.5", PCIe slot, SFP port, etc.), so it fits the original chassis without modification
- Equivalent or better performance — matched on RPM/IOPS/speed/throughput, never downgraded
- Same-brand-preferred — we list the OEM-equivalent first when available, then trusted aftermarket
- Warranty coverage — 90-day Pro Disk warranty on every part, with 1-year option for B2B
- In stock today — never recommend a part that is on backorder
Need help confirming compatibility?
Our engineers validate every replacement against your specific server, switch, or chassis model before shipment. Email sales@prodisknetwork.com with your platform model (e.g., Dell PowerEdge R740, HP DL380 Gen10, Cisco Catalyst 9300) and we will confirm the exact part number that drops into your hardware.