Replacement for P00645-B21: Drop-In Alternatives We Stock
Looking for a replacement for the P00645-B21 (P00645-B21 - HP 2.1GHz 32MB L3 Cache Socket SP3 AMD EPYC 7281 16-Core Processor)? Pro Disk Network ships HP drop-in replacements and equivalent modern parts from US inventory. Every alternate below is in-stock today with same-day shipping for orders placed before 2pm ET. If your unit is still under warranty, contact our engineering team — we offer cross-shipping for B2B customers on Net 30 terms.
About the P00645-B21
| SKU | P00645-B21 |
|---|---|
| Product | P00645-B21 - HP 2.1GHz 32MB L3 Cache Socket SP3 AMD EPYC 7281 16-Core Processor |
| Current price | $3,670.95 |
| Stock status | In Stock |
| Detail page | View P00645-B21 › |
Drop-in replacements for P00645-B21
Each part below is currently in our US warehouse, ships same-day for orders before 2pm ET, and includes our 90-day warranty. SKUs link to the full product page with photos, datasheets and B2B quote form.
P04858-L21 - HP 2.1GHz 32MB L3 Cache Socket SP3 AMD EPYC 7281 16-Core Processor
SKU: P04858-L21
Price: $3,670.95
P00645-L21 - HP 2.1GHz 32MB L3 Cache Socket SP3 AMD EPYC 7281 16-Core Processor
SKU: P00645-L21
Price: $3,670.95
881169-L21 - HP 2.4GHz 64MB L3 Cache Socket SP3 AMD EPYC 7351 16-Core Processor
SKU: 881169-L21
Price: $189.47
881169-B21 - HP 2.4GHz 64MB L3 Cache Socket SP3 AMD EPYC 7351 16-Core Processor
SKU: 881169-B21
Price: $189.47
881163-L21 - HP 2.0GHz 64MB L3 Cache Socket SP3 AMD EPYC 7551 32-Core Processor
SKU: 881163-L21
Price: $278.95
881163-B21 - HP 2.0GHz 64MB L3 Cache Socket SP3 AMD EPYC 7551 32-Core Processor
SKU: 881163-B21
Price: $278.95
881165-B21 - HP 2.3GHz 64MB L3 Cache Socket SP3 AMD EPYC 7451 24-Core Processor
SKU: 881165-B21
Price: $303.16
881166-L21 - HP 2GHz 64MB L3 Cache Socket SP3 AMD EPYC 7401 24-Core Processor
SKU: 881166-L21
Price: $1,494.21
881166-B21 - HP 2GHz 64MB L3 Cache Socket SP3 AMD EPYC 7401 24-Core Processor
SKU: 881166-B21
Price: $1,494.21
881170-B21 - HP 2.2GHz 64MB L3 Cache Socket SP3 AMD EPYC 7301 16-Core Processor
SKU: 881170-B21
Price: $1,730.42
881170-L21 - HP 2.2GHz 64MB L3 Cache Socket SP3 AMD EPYC 7301 16-Core Processor
SKU: 881170-L21
Price: $2,268.99
P04857-L21 - HP 2.2GHz 64MB L3 Cache Socket SP3 AMD EPYC 7301 16-Core Processor
SKU: P04857-L21
Price: $2,268.99
How we pick replacements
Every recommendation above was selected using these criteria:
- Drop-in compatibility — same form factor (2.5"/3.5", PCIe slot, SFP port, etc.), so it fits the original chassis without modification
- Equivalent or better performance — matched on RPM/IOPS/speed/throughput, never downgraded
- Same-brand-preferred — we list the OEM-equivalent first when available, then trusted aftermarket
- Warranty coverage — 90-day Pro Disk warranty on every part, with 1-year option for B2B
- In stock today — never recommend a part that is on backorder
Need help confirming compatibility?
Our engineers validate every replacement against your specific server, switch, or chassis model before shipment. Email sales@prodisknetwork.com with your platform model (e.g., Dell PowerEdge R740, HP DL380 Gen10, Cisco Catalyst 9300) and we will confirm the exact part number that drops into your hardware.